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     海法大学生物博士后开始招生

    [字号: ]
    2015-03-22

    Institute of Evolution ????????? ?????

    Bioinformatics Post-Doc Positions

    University of Haifa, Haifa, Israel

    You can be part of a fascinating project of a breakthrough in cancer treatment

    Looking for independent, motivated candidates with a proven background in bioinformatics and biology and good analytical skills, to reveal the mechanisms of cancer-resistance and anti-cancer activity of the

    Israeli Subterranean, Blind Mole-Rat, Spalax

    This unique mammal is hypoxia- tolerant (down to 3% O2), oxidative-stress adapted, long lived (>20 years; ~4-5 times longer than its relative, the rat) and cancer-free. No spontaneous tumors have ever been observed in thousands of individuals along >40 years of studies. Moreover, Spalax is highly resistant to chemical carcinogens-induced tumor development, which led to the expected cancer in 100% of mice and rats. Most fascinating, Spalax fibroblast cells, but not of other species, secrete substance/s, yet to be identified, that lead to the death of cancer cells (but not of normal cells) from different species, including human cancer cells originated from a wide range of tissues (Manov et al., BMC Biol, 2013).

    We recently sequenced its genome and discovered its unique organization (Fang et al., Nat. Comm, 2014). Further, differential gene expression from RNAseq data has revealed enrichment of genes that overlap cancer resistance, apoptosis, angiogenesis, and hypoxia-tolerance. (Malik et al., BMC Genomics, 2013)

    We want to understand how these changes are translated into protection from cancer, so we can develop novel treatment strategies.

    Applicants should be able to process large scale genomic data, such as raw RNA-seq, miR seq and Genomic sequencing, analyze the data, and biologically interpret it in high level. Accordingly, background in statistics, programming and scripting is required. (e.g., experience and knowledge in tools like Linux clusters, R, mysql, Matlab, perl, python, etc.). Background in cancer research and familiarity with TCGA [TheCancerGenomeAtlas] is an advantage.

    We can offer generous fellowships to candidates that will commit themselves for at least 2 years with a willingness to extend the period of their studies according to the needs of their project.

    Qualified applicants that can fulfill our expectations-Please submit an extended CV andbibliography, summary of past accomplishments, list of (importantly 1st authorship and peer-reviewed, respected impact factor journals) publications, and contact information of 3 referees to Dr. Aaron Avivi ( [email protected]l) AND Dr. Imad Shams ( [email protected]m)

    ( //evolution.haifa.ac.il/index.php/29-people/personal-websites/77-personal-site-avivi)

    Mount Carmel, Haifa 3498838, Israel, Phone: 972-48240446 :'?? 3498838 ???? ,????? ??

    Website: ///evolution.haifa.ac.il :??????? ??? Fax: 972-482465554:??? E-mail: [email protected] :?"???

     
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  • 券商打新偏爱“独角兽” 平均获配超2万股  47家券商浮盈150万元 2019-06-07
  • 所以,历史注定苏联模式是他的第一次浪潮的结束,第二次浪潮的发端。 2019-06-07
  • 以古鉴今,习近平多次提及屈原 2019-06-02
  • 水土保持-近在你身边-图解新闻 2019-05-28
  • 衡阳市公安局回应“交警执勤中倒地”事件:2人停职调查 2019-05-24
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  • 成都市工商局:6批电线电缆商品抽检不合格 2019-05-13
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  • 实拍世界最大消防飞机“超级水箱” 由波音747改装而成 2019-03-11